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Statistical Considerations for Analysis of Microarray Experiments
Sc HONS. Secondary data its major sources. Complete enumeration. Controlled experiments, Observational studies and Sample Surveys. Scrutiny of data for internal consistency and detection of errors in recording.
He received his B. He has taught at The University of Wisconsin since with two one--year visiting positions in India at the Indian Institute of Management and the Indian Statistical Institute He has been at the University of Wisconsin since , except for a one--semester visiting position at the University of Oslo in Descriptive Study of Data. Elements of Probability.
Jul 13, Gouri K. Bhattacharyya. John Wiley & Sons Each statistical concept or method is motivated by setting out its goal and then focusing on an . christmas-poem.info johnson) Contains interesting data sets used in the text but that.
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Microarray technologies enable the simultaneous interrogation of expressions from thousands of genes from a biospecimen sample taken from a patient. This large set of expressions generates a genetic profile of the patient that may be used to identify potential prognostic or predictive genes or genetic models for clinical outcomes. The aim of this article is to provide a broad overview of some of the major statistical considerations for the design and analysis of microarrays experiments conducted as correlative science studies to clinical trials. An emphasis will be placed on how the lack of understanding and improper use of statistical concepts and methods will lead to noise discovery and misinterpretation of experimental results. Clin Trans Sci ; Volume 4: — Microarray technologies were developed in the s in the field of molecular biology as a means of simultaneously measuring the expression of thousands of genes from a single sample. The use of microarrays has extended across the fields of basic science and translational research, and has changed the way investigators approach the scientific goals of discovery and validation.
You are currently using the site but have requested a page in the site. Would you like to change to the site? Gouri K. Bhattacharyya , Richard A. He received his B. He has taught at The University of Wisconsin since with two one-year visiting positions in India at the Indian Institute of Management and the Indian Statistical Institute Request permission to reuse content from this site.